Title of article
A Combinatorial Library of Indinavir Analogues and Its In Vitro and In Vivo Studies
Author/Authors
Yuan Cheng، نويسنده , , Thomas A. Rano، نويسنده , , Tracy T. Huening، نويسنده , , Fengqi Zhang، نويسنده , , Zhijian Lu، نويسنده , , William A. Schleif، نويسنده , , Lori Gabryelski، نويسنده , , David B. Olsen، نويسنده , , Mark Stahlhut، نويسنده , , Lawrence C. Kuo، نويسنده , , Jiunn H. Lin، نويسنده , , Xin Xu، نويسنده , , Lixia Jin، نويسنده , , Timothy V. Olah، نويسنده , , Debra A. McLoughlin، نويسنده , , Rick C. King، نويسنده , , Kevin T. Chapman، نويسنده , , James R. Tata، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
4
From page
529
To page
532
Abstract
A combinatorial library of 300HIV protease inhibitors has been synthesized. The library was screened against recombinant wild-type and mutant HIV-1 protease enzymes. The pharmacokinetics of the library was evaluated by dosing in dogs. Compounds that are notably more potent than indinavir and have favorable pharmacokinetic properties were identified.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792011
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