Title of article
Identification of Unique VLA-4 Antagonists from a Combinatorial Library
Author/Authors
Stephen E. de Laszlo، نويسنده , , Bing Li، نويسنده , , Ermengilda McCauley، نويسنده , , Gail Van Riper، نويسنده , , William K. Hagmann، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
4
From page
685
To page
688
Abstract
A combinatorial library of 28 pools of 180 compounds (345 diastereomers) was designed and prepared in support of the delineation of the SAR of two prototypical VLA-4 antagonists. Deconvolution of the active pools led to the identification of three novel series of VLA-4 antagonists with low nanomolar potencies.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792047
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