Title of article
Insertion of 2-Carboxysuccinate and Tricarballylic Acid Fragments into Cyclic-Pseudopeptides: New Antagonists for the Human Tachykinin NK-2 Receptor
Author/Authors
Nicholas J. S. Harmat، نويسنده , , Danilo Giannotti، نويسنده , , Rossano Nannicini، نويسنده , , Enzo Perrotta، نويسنده , , Marco Criscuoli، نويسنده , , Riccardo Patacchini، نويسنده , , Anna-Rita Renzetti، نويسنده , , Sandro Giuliani، نويسنده , , Maria Altamura، نويسنده , , Carlo A. Maggi، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
4
From page
693
To page
696
Abstract
A series of cyclic pseudopeptides were synthesized containing the sequence -Trp-Phe-( )-PheΨCH2NH-, the terminal ends of which were bound to 2-carboxy succinate or enantiomerically enriched tricarballylic acid to give the final cyclic structures. These two molecules and their subsequent derivatives were screened for h-NK2 receptor binding and functional antagonist activity on the rabbit urinary bladder.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792049
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