Title of article
A designed P1 cysteine mimetic for covalent and non-covalent inhibitors of HCV NS3 protease
Author/Authors
Frank Narjes، نويسنده , , Konrad F. Koehler، نويسنده , , Uwe Koch، نويسنده , , Benjamin Gerlach، نويسنده , , Stefania Colarusso، نويسنده , , Christian Steinkühler، نويسنده , , Mirko Brunetti، نويسنده , , Sergio Altamura، نويسنده , , Raffaele De Francesco، نويسنده , , Victor G. Matassa، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
4
From page
701
To page
704
Abstract
The difluoromethyl group was designed by computational chemistry methods as a mimetic of the canonical P1 cysteine thiol for inhibitors of the hepatitis C virus NS3 protease. This modification led to the development of competitive, non-covalent inhibitor 4 (Ki 30 nM) and reversible covalent inhibitors (6, Ki 0.5 nM; and 8Ki* 10 pM).
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792051
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