Title of article
Antibacterial activity of G6-quaternary ammonium derivatives of a lipophilic vancomycin analogue
Author/Authors
Timothy A. Blizzard، نويسنده , , Ronald M. Kim، نويسنده , , Jerry D. Morgan، نويسنده , , II، نويسنده , , Sheng-Jiang Chang، نويسنده , , Joyce Kohler، نويسنده , , Ruth Kilburn، نويسنده , , Kevin Chapman، نويسنده , , Milton L. Hammond، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
4
From page
849
To page
852
Abstract
A series of G6-amino derivatives of a lipophilic vancomycin analogue was prepared. Antibacterial activity of the analogues was inversely proportional to the degree of substitution of the G6-nitrogen. The fully substituted (quaternary) analogues were essentially inactive against vanA phenotype VREF strains but retained substantial activity against other bacteria, a profile reminiscent of teicoplanin.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792083
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