Title of article
Hydrophobic modifications at 1-phosphate of inositol 1,4,5-Trisphosphate analogues enhance receptor binding
Author/Authors
Waka Nakanishi، نويسنده , , Kazuya Kikuchi، نويسنده , , Takanari Inoue، نويسنده , , Kenzo Hirose، نويسنده , , Masamitsu Iino، نويسنده , , Tetsuo Nagano، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
3
From page
911
To page
913
Abstract
Inositol 1,4,5-trisphosphate (IP3) analogues were synthesized in order to investigate the importance of the environment of 1-phosphate of IP3 for strong binding to the IP3 receptor. Our results show that hydrophobic modifications of the 1-phosphate moiety enhance the binding affinity, with considerable latitude of substituent structure.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792099
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