Title of article
Benzoindoloquinolines interact with DNA tetraplexes and inhibit telomerase
Author/Authors
Patrizia Alberti، نويسنده , , Philippe Schmitt، نويسنده , , Chi Hung Nguyen، نويسنده , , Christian Rivalle، نويسنده , , Magali Hoarau، نويسنده , , David S. Grierson and Robert W. Carpick، نويسنده , , Jean-Louis Mergny، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
4
From page
1071
To page
1074
Abstract
Telomeric G-rich single-stranded DNA can adopt a G-tetraplex structure which has been shown to inhibit telomerase activity. We have examined benzoindoloquinolines derivatives for their ability to stabilize an intramolecular G-quadruplex. The increase in Tm value of the G-quadruplex was associated with telomerase inhibition in vitro.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792142
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