Title of article
Synthesis and structure–activity relationships of a novel series of HIV-1 protease inhibitors encompassing ABT-378 (Lopinavir)
Author/Authors
Hing L. Sham، نويسنده , , David A. Betebenner، نويسنده , , Xiaoqi Chen، نويسنده , , Ayda Saldivar، نويسنده , , Sudthida Vasavanonda، نويسنده , , Dale J. Kempf، نويسنده , , Jacob J. Plattner، نويسنده , , Daniel W. Norbeck، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
3
From page
1185
To page
1187
Abstract
The HIV protease inhibitor ABT-378 (Lopinavir) has a 2,6-dimethylphenoxyacetyl group in the P-2′ position. Analogues in which this group is replaced with various substituted phenyl or heteroaryl groups were synthesized and the structure–activity relationships explored.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792169
Link To Document