Antifungal Sordarins. part 3: synthesis and structure–Activity relationships of 2′,3′-Fused oxirane derivatives

A number of new 2′,3′-fused oxirane derivatives were synthesized for structure–activity relationship study. Many of these derivatives exhibit high potency against Candida spp. In addition, sordarin manno epoxide derivative 6 presents in vivo therapeutic effect in mice and is considered a promising antifungal lead within this series.