Title of article
Development of a genetic selection for catalytic antibodies
Author/Authors
Jeff Gildersleeve، نويسنده , , Jeff Janes، نويسنده , , Helle Ulrich، نويسنده , , Priscilla Yang، نويسنده , , Carlos Barbas، نويسنده , , Peter G. Schultz، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
4
From page
1691
To page
1694
Abstract
The design and evaluation of a new genetic selection system for evolving catalytic antibodies with aldolase activity are described. Through a series of model selections, we have identified selection conditions where expression of a catalytically active antibody confers a growth advantage to Escherichia coli. In addition, we provide evidence that the growth advantage is a direct result of catalytic activity.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792290
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