Antifungal sordarins. Part 4: synthesis and structure–activity relationships of 3′,4′-fused alkyl-tetrahydrofuran derivatives

A series of Sordarin derivatives bearing alkyl substituted tetrahydrofuran rings fused to C3′–C4′ bond of the sugar moiety have been prepared and their antifungal properties evaluated. Most of them show remarkable antifungal activity against Candida spp and Cryptococcus neoformans.