Title of article
Structure-based design and synthesis of HIV-1 protease inhibitors employing β- -mannopyranoside scaffolds
Author/Authors
Paul V. Murphy، نويسنده , , Julie L. OʹBrien، نويسنده , , Lorraine J. Gorey-Feret، نويسنده , , Amos B. Smith III، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
4
From page
1763
To page
1766
Abstract
A preliminary account on the structure-based design, synthesis and evaluation of peptidomimetic inhibitors of HIV-1 protease containing β- -mannopyranoside scaffolds is given. The compounds prepared had IC50 values in the micromolar range. The results provide a platform for the development of more potent carbohydrate-based inhibitors of HIV-1 and other aspartic proteases.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792308
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