Title of article
Convenient synthesis of human calcitonin and its methionine sulfoxide derivative
Author/Authors
Tiesheng Shi، نويسنده , , Dallas L. Rabenstein، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
4
From page
2237
To page
2240
Abstract
The human calcitonin peptide chain was assembled using Fmoc solid-phase peptide synthesis chemistry. The combinations of cleavage Reagent H with trans-[Pt(en)2Cl2]2+ and Reagents B, K, and R with trans-[Pt(CN)4Cl2]2− provide convenient methods for the synthesis of human calcitonin and its methionine sulfoxide derivative; the formation of intramolecular disulfide bonds by the above Pt(IV) oxidants is essentially quantitative.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792417
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