Title of article
Synthesis and DNA binding properties of saturated distamycin analogues
Author/Authors
Craig R. Woods، نويسنده , , Nicolas Faucher، نويسنده , , Bernd Eschgfaller، نويسنده , , Kenneth W. Bair، نويسنده , , Dale L. Boger، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
4
From page
2647
To page
2650
Abstract
A series of saturated heterocyclic analogues of distamycin were prepared and examined. A fluorescent intercalator displacement (FID) assay conducted on p[dA]–p[dT] DNA to obtain C50 values and a hairpin deoxyoligonucleotide containing an A/T-rich binding site was used to evaluate DNA binding affinity. It is observed that saturated heterocycles greatly reduce the DNA binding relative to distamycin.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792514
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