Analogue based design of MMP-13 (Collagenase-3) inhibitors

3D-QSAR studies using MFA and RSA methods were performed on a series of 39 MMP-13 inhibitors. Model developed by MFA method has a r2cv (cross-validated) of 0.616 while its r2 (conventional) value is 0.822. For the RSA model r2cv and r2 are 0.681 and 0.847, respectively. Both the models indicate good internal as well as external predictive abilities. These models provide crucial information about the field descriptors for the design of potential inhibitors of MMP-13.