Title of article
New Rev-transport inhibitor with anti-HIV activity from Valerianae Radix
Author/Authors
Nobutoshi Murakami، نويسنده , , Ying Ye، نويسنده , , Motoyuki Kawanishi، نويسنده , , Shunji Aoki، نويسنده , , Nobuaki Kudo، نويسنده , , Minoru Yoshida، نويسنده , , Emi E. Nakayama، نويسنده , , Tatsuo Shioda، نويسنده , , Motomasa Kobayashi، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
4
From page
2807
To page
2810
Abstract
Bioassay-guided separation by use of the fission yeast expressing NES of Rev, a HIV-1 viral regulatory protein, resulted in isolation of valtrate (1) as a new Rev-transport inhibitor from the nucleus to cytoplasm from Valerianae Radix. Valtrate (1) also inhibited the p-24 production of HIV-1 virus without showing any cytotoxicity against the host MT-4 cells.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792546
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