Title of article
Antitumor agents. Part 215:: Antitubulin effects of cytotoxic B-Ring modified allocolchicinoids
Author/Authors
Shiqing Han، نويسنده , , Ernest Hamel، نويسنده , , Kenneth F. Bastow، نويسنده , , Andrew T. McPhail، نويسنده , , Arnold Brossi، نويسنده , , Kuo-Hsiung Lee، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
3
From page
2851
To page
2853
Abstract
N-Acetylcolchinol methyl ether 1 served as the starting material to prepare the chloroacetamide (3) and epoxide (5) analogues. Both 3 and 5 were potent inhibitors of tubulin polymerization in vitro. Compound 3 was also 4-fold more cytotoxic than colchicine against the 1A9 tumor cell line and showed a unique cross-resistance profile.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792556
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