• Title of article

    Molecular modeling and enzymatic studies of the interaction of a choline analogue and acetylcholinesterase

  • Author/Authors

    Stefano Alcaro، نويسنده , , Luigi Scipione، نويسنده , , Francesco Ortuso، نويسنده , , Salvatore Posca، نويسنده , , Vincenzo Rispoli، نويسنده , , Domenicantonio Rotiroti، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 2002
  • Pages
    7
  • From page
    2899
  • To page
    2905
  • Abstract
    Pivaloyl-choline iodide 1 interactions with acetylcholinesterase (AChE) have been studied by theoretical and enzymatic methods. An integrated computational approach has clearly shown a substrate rather than inhibitory profile for 1. Enzymatic experiments have also supported the same theoretical conclusion indicating that AChE was able to hydrolyze 1 to choline.
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Serial Year
    2002
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Record number

    792567

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=792567