Title of article
Substituted 4-anilino-7-phenyl-3-quinolinecarbonitriles as Src kinase inhibitors
Author/Authors
Dan Berger، نويسنده , , Minu Dutia، نويسنده , , Dennis Powell، نويسنده , , Allan Wissner، نويسنده , , Frenel DeMorin، نويسنده , , Yuri Raifeld، نويسنده , , Jennifer Weber، نويسنده , , Frank Boschelli، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
4
From page
2989
To page
2992
Abstract
A series of substituted 4-anilino-7-phenyl-3-quinolinecarbonitriles has been prepared as Src kinase inhibitors. Optimal activity is observed with compounds that have basic amines attached via the para position of the 7-phenyl ring, and a hydrogen atom at the C-6 position. The best compounds are low nanomolar inhibitors of Src kinase, and have potent activity against Src-transformed fibroblast cells.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792585
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