Title of article
α-Bromoacetophenone derivatives as neutral protein tyrosine phosphatase inhibitors: structure–Activity relationship
Author/Authors
Gulnur Arabaci، نويسنده , , Tian Yi، نويسنده , , Hua Fu، نويسنده , , Mary E. Porter، نويسنده , , Kirk D. Beebe، نويسنده , , Dehua Pei and Wim G. J. Hol، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
4
From page
3047
To page
3050
Abstract
A series of α-haloacetophenone derivatives was tested for inhibition of protein tyrosine phosphatases SHP-1 and PTP1B. The results show that the bromides are much more potent than the corresponding chlorides, whereas the phenyl ring is remarkably tolerant to modifications. Derivatization of the phenyl ring with a tripeptide Gly-Glu-Glu resulted in a potent, selective inhibitor against PTP1B
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792596
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