Title of article
Synthesis and structure–activity relationship of novel aminotetralin derivatives with high μ selective opioid affinity
Author/Authors
Caroline Roy، نويسنده , , Ticheao Li، نويسنده , , Pavel Krasik، نويسنده , , Marie-Josée Gilbert، نويسنده , , Christine Pelletier، نويسنده , , Diane Gagnon، نويسنده , , Ed Robert، نويسنده , , Julie Ducharme، نويسنده , , Richard Storer، نويسنده , , Jean-François Lavallée، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
3
From page
3141
To page
3143
Abstract
Several novel racemic aminotetralin derivatives have been prepared using a stereoselective aziridine ring opening reactions and were evaluated for their μ-opioid receptor binding affinity. Selectivity index towards other opioid receptors and antinociceptive activity in mice have been evaluated for the most potent derivatives.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792618
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