Title of article
The antimicrobial natural product chuangxinmycin and Some synthetic analogues are potent and selective inhibitors of bacterial tryptophanyl tRNA synthetase
Author/Authors
Murray J. Brown، نويسنده , , Paul S. Carter، نويسنده , , Ashley E. Fenwick، نويسنده , , Andrew P. Fosberry، نويسنده , , Dieter W. Hamprecht، نويسنده , , Martin J. Hibbs، نويسنده , , Richard L. Jarvest، نويسنده , , Lucy Mensah، نويسنده , , Peter H. Milner، نويسنده , , Peter J. OʹHanlon، نويسنده , , Andrew J. Pope، نويسنده , , Christine M. Richardson، نويسنده , , Andrew-West، نويسنده , , David R. Witty، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
4
From page
3171
To page
3174
Abstract
The antimicrobial natural product chuangxinmycin has been found to be a potent and selective inhibitor of bacterial tryptophanyl tRNA synthetase (WRS). A number of analogues have been synthesised. The interaction with WRS appears to be highly constrained, as only sterically smaller analogues afforded significant inhibition. The only analogue to show inhibition comparable to chuangxinmycin also had antibacterial activity. WRS inhibition may contribute to the antibacterial action of chuangxinmycin.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792625
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