Title of article
Prodrugs of 4′-demethyl-4-deoxypodophyllotoxin: synthesis and evaluation of the antitumor activity
Author/Authors
Yong Kim، نويسنده , , Young-Jae You، نويسنده , , Nguyen-Hai Nam، نويسنده , , Byung-Zun Ahn، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
4
From page
3435
To page
3438
Abstract
A series of prodrugs of 4′-demethyl-4-deoxypodophyllotoxin (DDPT) including carbamates (3–8), a carbonate (9) and water-soluble amino acid derivatives (10–17) were prepared and tested for their antitumor activity. The carbamate 6 (2-hydroxyethylcarbamoyl-DDPT), carbonate 9 (2-chloroethyloxycarbonyl-DDPT), and most of amino acid prodrugs (12–17) showed enhanced antitumor activity.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792686
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