Inhibitors of NF-κB signaling: design and synthesis of a biotinylated isopanepoxydone affinity reagent

A number of inhibitors of NF-κB signaling arising from our recent syntheses of isopanepoxydone and panepoxydone have been identified. Structure–activity data have been correlated to allow the design and synthesis of an affinity reagent for the isolation and identification of any relevant cellular target.