Title of article
Characterization of mono- and diaminopyrimidine derivatives as novel, nonpeptide gonadotropin releasing hormone (GnRH) receptor antagonists
Author/Authors
David R. Luthin، نويسنده , , Yufeng Hong، نويسنده , , Eileen Tompkins، نويسنده , , Kenna L. Anderes، نويسنده , , Genevieve Paderes، نويسنده , , Eugenia A. Kraynov، نويسنده , , Mary A. Castro، نويسنده , , Karen D. Nared-Hood، نويسنده , , Rosemary Castillo، نويسنده , , Margaret Gregory، نويسنده , , Haresh Vazir، نويسنده , , John M. May، نويسنده , , Mark B. Anderson، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
5
From page
3635
To page
3639
Abstract
A novel series of derivatives of mono- and diaminopyrimidines 1 potently displaced binding of a radiolabeled GnRH analogue to human and rat GnRH receptors. Analogues from these series competitively antagonized GnRH-stimulated increases in extracellular acidification in vitro and suppressed GnRH-mediated increases in circulating luteinizing hormone (LH) in castrated rats and testosterone in intact rats. These compounds or their analogues may be useful in treating sex hormone-dependent disease.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792730
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