Title of article
Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 3
Author/Authors
Ken-ichi Kawasaki، نويسنده , , Miyako Masubuchi، نويسنده , , Kenji Morikami، نويسنده , , Satoshi Sogabe، نويسنده , , Tsunehisa Aoyama، نويسنده , , Hirosato Ebiike، نويسنده , , Satoshi Niizuma، نويسنده , , Michiko Hayase، نويسنده , , Toshihiko Fujii، نويسنده , , Kiyoaki Sakata، نويسنده , , Hidetoshi Shindoh، نويسنده , , Yasuhiko Shiratori، نويسنده , , Yuko Aoki، نويسنده , , Tatsuo Ohtsuka، نويسنده , , Nobuo Shimma، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
5
From page
87
To page
91
Abstract
A new series of acid-stable antifungal agents having strong inhibitory activity against Candida albicans N-myristoyltransferase (CaNmt) has been developed starting from acid-unstable benzofuranylmethyl aryl ether 2. The inhibitor design is based on X-ray crystallographic analysis of a CaNmt complex with aryl ether 3. Among the new inhibitors, pyridine derivative 8b and benzimidazole derivative 8k showed clear antifungal activity in a murine systemic candidiasis model.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792866
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