Title of article
Synthesis and GABAA receptor activity of a 6,19-Oxido analogue of pregnanolone
Author/Authors
Adriana S. Veleiro، نويسنده , , Ruth E. Rosenstein، نويسنده , , Carolina O. Jaliffa، نويسنده , , Mar?a L. Grilli، نويسنده , , Florencia Speroni، نويسنده , , Gerardo Burton، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
343
To page
346
Abstract
3α-Hydroxy-6,19-oxidopregn-4-ene-20-one (4) was prepared in seven steps from pregnanolone acetate. At 0.1 μM concentration 4 significantly increased GABA induced 36Cl− influx in hamster cerebral cortex synaptoneurosomes while at 20 mg/kg it decreased the percentage of hamsters showing seizures induced by 3-mercaptopropionic acid.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792919
Link To Document