Title of article
Synthesis and In vitro efficacy of acid-Sensitive poly(ethylene glycol) paclitaxel conjugates
Author/Authors
Paula C. A. Rodrigues، نويسنده , , Karin Scheuermann، نويسنده , , Cornelia Stockmar، نويسنده , , Gerhard Maier، نويسنده , , Heinz H. Fiebig، نويسنده , , Clemens Unger، نويسنده , , Rolf Mülhaupt، نويسنده , , Felix Kratz، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
6
From page
355
To page
360
Abstract
Three maleimide derivatives of the anticancer drug paclitaxel that incorporate an acid-sensitive carboxylic hydrazone linker were prepared and coupled to bifunctional PEGs (MW 20,000 g/mol). The conjugates showed in vitro activity in three human cancer lines in the low micromolar range.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792922
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