Title of article
Synthesis and SAR of α-Acylaminoketone ligands for control of gene expression
Author/Authors
Colin M. Tice، نويسنده , , Robert E. Hormann، نويسنده , , Christine S. Thompson، نويسنده , , Jennifer L. Friz، نويسنده , , Caitlin K. Cavanaugh، نويسنده , , Enrique L. Michelotti، نويسنده , , Javier Garcia، نويسنده , , Ernesto Nicolas، نويسنده , , Fernando Albericio، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
475
To page
478
Abstract
A lead discovery library and a follow-up focused library of α-acylaminoketones were designed based on known dibenzoylhydrazine ecdysone agonists, including GS™–E. The compounds were assayed in mammalian cells expressing the ecdysone receptor from Bombyx mori for their ability to cause expression of a reporter gene downstream of an ecdysone response element. The most potent α-acylaminoketones were comparable to GS™–E in this assay.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792948
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