Title of article
A structure–Permeability study of small drug-like molecules
Author/Authors
Thomas Fichert، نويسنده , , Mehran Yazdanian، نويسنده , , John R. Proudfoot، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
719
To page
722
Abstract
A systematic structure–permeability relationship study on a set of small drug-like molecules with log D values in the range −2.5 to 3 and carrying a diverse array of functionality reveals that the compounds with log D>0 and <3 are highly permeable. Surprisingly, several tetrazole derivatives were found to be substrates for efflux pump(s).
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793001
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