Title of article
Antiplatelet activity of synthetic pyrrolo-benzylisoquinolines
Author/Authors
Reen-Yen Kuo، نويسنده , , Chin-Chung Wu، نويسنده , , Fang-Rong Chang، نويسنده , , Jwu-Lai Yeh، نويسنده , , Ing-Jun Chen، نويسنده , , Yang-Chang Wu، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
3
From page
821
To page
823
Abstract
Pyrrolo-benzylisoquinolines were prepared as target compounds and their antiplatelet aggregation activity, adreno-receptor affinity, and cytotoxicity were screened. Compounds 1d–9d showed specific antiplatelet aggregation activity induced by arachidonic acid and collagen. Among them, 8d and 9d exhibited better activity than the reference drug, aspirin and 9d also showed inhibition of platelet aggregation by all four inducers.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793023
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