Title of article
Cytotoxic activity of 6-alkynyl- and 6-alkenylpurines
Author/Authors
Anders Br?the، نويسنده , , Lise-Lotte Gundersen، نويسنده , , Jon Nissen-Meyer، نويسنده , , Frode Rise، نويسنده , , Bj?rn Spilsberg، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
877
To page
880
Abstract
6-Alkynyl- and 6-alkenylpurines have been screened for cytotoxic activity against a human chronic myelogenous leukemia cell line; K-562 cells using a [3H]-thymidine incorporation assay. Most alkynes displayed cytotoxicity comparable to, or better than, the known anticancer drugs 6-mercaptopurine and fludarabine. The 6-alkenylpurines, which are promising plant growth stimulators and 15-lipoxygenase inhibitors, exhibited only low toxicity.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793036
Link To Document