Title of article
Structure–activity relationships studies of the anti-angiogenic activities of linomide
Author/Authors
Jiandong Shi، نويسنده , , Zili Xiao، نويسنده , , Michael A. Ihnat، نويسنده , , Chandrashekhar Kamat، نويسنده , , Bulbul Pandit، نويسنده , , Zhigen Hu، نويسنده , , Pui-Kai Li، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
3
From page
1187
To page
1189
Abstract
The synthesis and anti-angiogenic activities of linomide and its analogues are reported. Three of the analogues are 3.3–69 times more potent than linomide at inhibiting blood vessel formation in the CAM angiogenesis assay. These compounds possessed considerable anti-proliferative activity against isolated HUVEC cells with no activity against epithelial-derived prostate tumor cells.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793103
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