Title of article
A new synthesis of cytoxazone and its diastereomers provides key initial SAR information
Author/Authors
Percy H. Carter، نويسنده , , Jacob R. LaPorte، نويسنده , , Peggy A. Scherle، نويسنده , , Carl P. Decicco، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
3
From page
1237
To page
1239
Abstract
A short, enantioselective, and diastereoselective synthesis of cytoxazone, a Th2-selective immunomodulator from Streptomyces, is described. The route was readily adapted to the synthesis of the three other stereoisomers of natural cytoxazone. Evaluation of these compounds revealed that the stereochemical configuration of the oxazolidinone ring did not influence their biological activity.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793112
Link To Document