Title of article
Microsomal triglyceride transfer protein inhibitors: discovery and synthesis of alkyl phosphonates as potent MTP inhibitors and cholesterol lowering agents
Author/Authors
David R. Magnin، نويسنده , , Scott A. Biller، نويسنده , , John Wetterau، نويسنده , , Jeffrey A. Robl، نويسنده , , John K. Dickson Jr.، نويسنده , , Prakash Taunk، نويسنده , , Thomas W. Harrity، نويسنده , , R. Michael Lawrence، نويسنده , , C. -Q. Sun، نويسنده , , Tammy Wang، نويسنده , , Janette Logan، نويسنده , , Olga Fryszman، نويسنده , , Fergal Connolly، نويسنده , , Kern Jolibois، نويسنده , , Lori Kunselman، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
1337
To page
1340
Abstract
A series of newly synthesized phosphonate esters were evaluated for their effects on microsomal triglyceride transfer protein activity (MTP). The most potent compounds were evaluated for their ability to inhibit lipoprotein secretion in HepG2 cells and to affect VLDL secretion in rats. These inhibitors were also found to lower serum cholesterol levels in a hamster model upon oral dosing.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793136
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