Title of article
Synthesis and evaluation of a novel series of farnesyl protein transferase inhibitors as non-peptidic CAAX tetrapeptide analogues
Author/Authors
Michel Pérez، نويسنده , , Catherine Maraval، نويسنده , , Stephan Dumond، نويسنده , , Marie Lamothe، نويسنده , , Philippe Schambel، نويسنده , , Chantal Etiévant، نويسنده , , Bridget Hill، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
1455
To page
1458
Abstract
A novel series of compounds, derived from 4-amino-phenyl piperazine, has been designed to selectively inhibit farnesyl protein transferase (FPTase) as CAAX tetrapeptide analogues. Certain of these compounds were shown to possess low nanomolar inhibitory activity both against the isolated enzyme and in cultured cells.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793162
Link To Document