Title of article
A novel metal-Chelating inhibitor of protein farnesyltransferase
Author/Authors
Akiyuki Hamasaki، نويسنده , , Hayato Naka، نويسنده , , Fuyuhiko Tamanoi، نويسنده , , Kazuo Umezawa، نويسنده , , Masami Otsuka، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
1523
To page
1526
Abstract
A novel metal chelator comprising a 4-(naphthalen-1-yl)pyridine and 2-aminoethanethiol was synthesized. This showed inhibitory activity against human protein farnesyltransferase with IC50 1.9 μM, induced morphological change in K-ras-NRK cells at 0.5 μg/mL and showed growth inhibition of K-ras-NRK cells with IC50 0.32 μg/mL.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793176
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