Title of article
5-Aryl-pyrazolo[3,4-b]pyridazines: potent inhibitors of glycogen synthase kinase-3 (GSK-3)
Author/Authors
Jason Witherington، نويسنده , , Vincent Bordas، نويسنده , , David Haigh، نويسنده , , Deirdre M. B. Hickey، نويسنده , , Robert J. Ife، نويسنده , , Anthony D. Rawlings، نويسنده , , Brian P. Slingsby، نويسنده , , David G. Smith، نويسنده , , Robert W. Ward، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
1581
To page
1584
Abstract
Introduction of a nitrogen atom into the 6-position of a series of pyrazolo[3,4-b]pyridines led to a dramatic improvement in the potency of GSK-3 inhibition. Rationalisation of the binding mode suggested participation of a putative structural water molecule, which was subsequently confirmed by X-ray crystallography.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793190
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