Title of article
Novel 6,7-diphenyl-2,3,8,8a-tetrahydro-1H-indolizin-5-one analogues as cytotoxic agents
Author/Authors
Vedula M. Sharma، نويسنده , , K. V. Adi Seshu، نويسنده , , C. Vamsee Krishna، نويسنده , , P. Prasanna، نويسنده , , V. Chandra Sekhar، نويسنده , , A. Venkateswarlu، نويسنده , , Sriram Rajagopal، نويسنده , , R. Ajaykumar، نويسنده , , Dhanvanthri S. Deevi، نويسنده , , N. V. S. Rao Mamidi، نويسنده , , R. Rajagopalan، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
1679
To page
1682
Abstract
A series of 6,7-diphenyl-2,3,8,8a-tetrahydro-1H-indolizin-5-one analogues were synthesized and evaluated for cytotoxic activity against eight human cancer cell lines. Compounds 18, 21, 28, 29, 30 and 31 showed cytotoxic activity with GI50 values in the range of 2.1–8.1 μM concentration. Among these, compounds 21 and 28 exhibited good pharmacokinetic properties. These compounds were further evaluated for their in vivo efficacy in modified hollow fibre assay (HFA).
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793210
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