Title of article
Synthesis and activity of a C-8 keto pleuromutilin derivative
Author/Authors
Dane M. Springer، نويسنده , , Margaret E. Sorenson، نويسنده , , Stella Huang، نويسنده , , Timothy P. Connolly، نويسنده , , Joanne J. Bronson، نويسنده , , James A. Matson، نويسنده , , Ronald L. Hanson، نويسنده , , David B. Brzozowski، نويسنده , , Thomas L. LaPorte، نويسنده , , Ramesh N. Patel، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
3
From page
1751
To page
1753
Abstract
A C-8 keto pleuromutilin derivative has been synthesized from the biotransformation product 8-hydroxy mutilin. A key step in the process was the selective oxidation at C-8 of 8-hydroxy mutilin using tetrapropylammonium perruthenate. The presence of the C-8 keto group precipitated interesting intramolecular chemistry to afford a compound (10) with a novel pleuromutilin-derived ring system.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793227
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