Title of article
Tetrahydroquinoline-Based selective estrogen receptor modulators (SERMs)
Author/Authors
Owen B. Wallace، نويسنده , , Kenneth S. Lauwers، نويسنده , , Scott A. Jones، نويسنده , , Jeffrey A. Dodge، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
1907
To page
1910
Abstract
A new series of estrogen receptor ligands based on a 6-hydroxy-tetrahydroquinoline scaffold is described, in addition to their binding affinity and functional activity in MCF-7 cells. Several 1,2-disubstituted tetrahydroquinolines bearing a basic side chain were shown to be high affinity ligands and antagonists in the MCF-7 proliferation assay. Compounds lacking the basic side chain were agonists in the MCF-7 assay.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793262
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