Title of article
Polyacylated neohesperidosides From Geranium caespitosum: bacterial multidrug resistance pump inhibitors
Author/Authors
Frank R. Stermitz، نويسنده , , Kevin K. Cashman، نويسنده , , Kathleen M. Halligan، نويسنده , , Cécile Morel، نويسنده , , George P. Tegos، نويسنده , , Kim Lewis، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
1915
To page
1918
Abstract
Bioassay-directed fractionation for Staphylococcus aureus multidrug resistance efflux pump inhibitors resulted in isolation of novel acylated neohesperidosides from Geranium caespitosum. The more highly acylated compounds had no direct activity against S. aureus, but potentiated activity of the antibiotics berberine, rhein, ciprofloxacin and norfloxacin. Cellular concentrations of berberine were greatly increased in the presence of active esters.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793264
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