Title of article
Antifungal activity of a Candida albicans GGTase I inhibitor-Alanine conjugate. inhibition of Rho1p prenylation in C. albicans
Author/Authors
Krishna K. Murthi، نويسنده , , Susan E. Smith، نويسنده , , Arthur F. Kluge، نويسنده , , Gustave Bergnes، نويسنده , , Patrick Bureau، نويسنده , , Vivian Berlin، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
3
From page
1935
To page
1937
Abstract
An alanine conjugate of a Candida albicans geranylgeranyl transferase I inhibitor was synthesized to facilitate its uptake into the fungal cell. The antifungal activity of CaGGTase-Ala conjugate is demonstrated. It is also shown that the CaGGTase-Ala conjugate affects prenylation of endogenous Rho1p, but has no effect on prenylation of endogenous Ras1p.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793269
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