Title of article
Chemoenzymatic synthesis of (E)-3,7-dimethyl-2-octene-1,8-diol isolated from the hairpencils of male danaus chrysippus (African monarch)
Author/Authors
Kunihiko Takabe، نويسنده , , Nobuyuki Mase، نويسنده , , Hiroya Hashimoto، نويسنده , , Atsushi Tsuchiya، نويسنده , , Takashi Ohbayashi، نويسنده , , Hidemi Yoda، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
3
From page
1967
To page
1969
Abstract
The synthesis of (E)-3,7-dimethyl-2-octene-1,8-diol (1), which was isolated from the hairpencils of male Danaus chrysippus (African Monarch), was investigated. The key step of the sequence involves asymmetric desymmetrization of the 1,3-propanediol 7 with lipase, in which high enantioselectivity was observed. Total synthesis afforded (S)-1 in 12 steps and 26% overall yield from readily available geraniol.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793276
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