Title of article
Unexpected inhibition of S-adenosyl- -homocysteine hydrolase by a guanosine nucleoside
Author/Authors
Katherine L. Seley، نويسنده , , Stephen Quirk، نويسنده , , Samer Salim، نويسنده , , Liang Zhang، نويسنده , , Asmerom Hagos، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
1985
To page
1988
Abstract
A series of shape-modified flexible nucleosides (‘fleximers’, 1, 2, and 3) was modeled, synthesized and subsequently assayed against S-adenosyl- -homocysteine hydrolase (SAHase). No inhibitory activity was observed for the adenosine fleximer, which served as a substrate, but moderate inhibitory activity was exhibited by the guanosine fleximers. This is the first known report of a guanosine nucleoside analogue possessing activity against SAHase.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793280
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