Title of article
Antitumor agents. Part 218: Cappamensin A, a new In vitro anticancer principle, from Capparis sikkimensis
Author/Authors
Jiu-Hong Wu، نويسنده , , Fang-Rong Chang، نويسنده , , Kenichiro Hayashi، نويسنده , , Hiroaki Shiraki، نويسنده , , Chih-Chuang Liaw، نويسنده , , Yuka Nakanishi، نويسنده , , Kenneth F. Bastow، نويسنده , , Donglei Yu، نويسنده , , Ih-Sheng Chen، نويسنده , , Kuo-Hsiung Lee، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
3
From page
2223
To page
2225
Abstract
A new inhibitor of in vitro tumor cell replication, cappamensin A (1) (2H-1,4-benzoxazin-3(4H)-one, 6-methoxy-2-methyl-4-carbaldehyde), was isolated from the roots of Capparis sikkimensis subsp. formosana using bioactivity-guided fractionation. The structure of 1 was established by spectroscopic methods, including 2D NMR analyses. Compound 1 displayed significant in vitro anticancer activity against ovarian (1A9), lung (A549), ileocecal (HCT-8), breast (MCF-7), nasopharyngeal (KB), and vincristine resistant (KB-VIN) human tumor cell lines with ED50 values ≤4 μg/mL (mean GI50 value of 15.1 μM).
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793330
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