Title of article
Effect of catechol derivatives on cell growth and lipoxygenase activity
Author/Authors
Julie Simpson، نويسنده , , Rebecca Forrester، نويسنده , , Michael J. Tisdale، نويسنده , , David C. Billington، نويسنده , , Daniel L. Rathbone، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
5
From page
2435
To page
2439
Abstract
Derivatives of salicylic acid have been synthesized as potential lipoxygenase inhibitors. Agents containing a phenolic dihydroxy moiety showed potent (IC5010−6–10−7 M) inhibition of the growth of murine colonic tumour cells in vitro, and were effective inhibitors of 5-, 12- and 15-lipoxygenase in intact cells. The catechols were also potent inhibitors of rabbit reticulocyte 15-lipoxygenase (IC50 1 μM).
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793372
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