Title of article
Are 5′-O-Carbamate-2′,3′-dideoxythiacytidine New Anti-HIV and Anti-HBV nucleoside Drugs or Prodrugs?
Author/Authors
Carole Anastasi، نويسنده , , Patrick Vlieghe، نويسنده , , Olivier Hantz، نويسنده , , Olivier Schorr، نويسنده , , Christophe Pannecouque، نويسنده , , Myriam Witvrouw، نويسنده , , Erik De Clercq، نويسنده , , Pascal Clayette، نويسنده , , Nathalie Dereuddre-Bosquet، نويسنده , , Dominique Dormont، نويسنده , , Françoise Gondois-Rey، نويسنده , , Ivan Hirsch، نويسنده , , Jean-Louis Kraus، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
5
From page
2459
To page
2463
Abstract
In contrast to 5′-O-carbonate 3TC derivatives (23, 24), which are clearly 3TC prodrugs, the corresponding 3TC carbamates (15–21 and 25), found to be very stable compounds with respect to enzymatic hydrolysis (cellular lysates and culture cell media) and still active on both HIV-1 and HBV infected cells, may not be 3TC prodrugs. The antiviral properties as well as the mechanism of action of 3TC analogues have been studied and evaluated.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793377
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