Title of article
Synthesis and biological evaluation of gambierol analogues
Author/Authors
Haruhiko Fuwa، نويسنده , , Noriko Kainuma، نويسنده , , Masayuki Satake، نويسنده , , Makoto Sasaki، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
2519
To page
2522
Abstract
Gambierol is a polycyclic ether toxin, isolated as a toxic constituent from the marine dinoflagellate Gambierdiscus toxicus. We describe here the synthesis and biological evaluation of structural analogues of gambierol. The present preliminary structure–activity relationship studies clearly indicate that the H ring functionality and the unsaturated side chain of gambierol are crucial for its potent toxicity.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793390
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