Title of article
Facile preparation of DNA-tagged carbohydrates
Author/Authors
Shinsuke Sando، نويسنده , , Kazuki Matsui، نويسنده , , Yusuke Niinomi، نويسنده , , Nobuhiko Sato، نويسنده , , Yasuhiro Aoyama، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
2633
To page
2636
Abstract
We report here that unprotected carbohydrates (maltose, lactose, cellobiose, and maltoheptaose) can be attached to the aminoalkylated oligonucleotides under mild reductive-amination conditions (aqueous borate buffer, pH 8.0, NaBH3CN, 60 °C) without notable side reactions. Quadruplex-forming G-rich oligonucleotide, 5′-aminoalkyl d(TGGGGT), is glycosylated with maltoheptaose to afford a novel DNA-assisted tetrasaccharide cluster motif.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793415
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